Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute

The goal of this project is to elucidate the molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease (NPC). We will investigate the role of protease BACE1, the key Alzheimer's disease (AD) enzyme, in the pathogenesis of NPC disease. We hope that our findings will elucidate BACE1 as a novel target for treating/ameliorating NPC disease.

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Frontiers Dissecting the Molecular Mechanisms of

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IJMS, Free Full-Text

PDF] Molecular mechanisms of neurodegeneration in Alzheimer's

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Promoting the clearance of neurotoxic proteins in

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Niemann-Pick-C desease - CERMO-FC

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Niemann–Pick type C disease: cellular pathology and

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Marko Košiček - Science communication coordinator - Ruđer Bošković

Modeling Brain Pathology of Niemann‐Pick Disease Type C Using